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Case Reports
. 2002 Mar;22(6):459-62.
doi: 10.1007/s100720200006.

P300 and executive function alterations: possible links in a case of Morgagni-Stewart-Morel syndrome

K S Paulus  1 , I Magnano, I Aiello, G P Sechi, G Rosati, A R Casu, M R Piras, R Cherchi, S Sotgiu
Affiliations
Case Reports

P300 and executive function alterations: possible links in a case of Morgagni-Stewart-Morel syndrome

K S Paulus et al. Neurol Sci. 2002 Mar.

Abstract

To evaluate possible cause-effect relationships between hyperostosis frontalis interna and cognitive dysfunction, we performed a neurophysiological (event-related potentials, ERPs) and neuropsychological study in a case of Morgagni-Stewart-Morel (MSM) syndrome associated with frontal lobe compression. Neuropsychological evaluation evidenced selective impairment of executive function. Visual and auditory oddball ERPs revealed delayed P300 latency and reduced auditory P300 amplitude with multi-peaked morphology. ERP abnormalities and cognitive dysfunction could be due to the frontal bone-cortex conflict documented by neuroradiological investigations.

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