Leukocyte transendothelial migration: a junctional affair

Abstract

A critical function of the inflammatory response is delivery of leukocytes to a site of injury, immune reaction or infection. Considerable information is available concerning the molecular mechanisms that capture flowing leukocytes and initiate their stable arrest on the lumenal surface of the blood vessel wall. In comparison, much less is known about the subsequent step(s) in migration of circulating blood leukocytes across endothelial cell-to-cell lateral borders to underlying tissues. This article will focus on the endothelial-dependent processes that coordinate transmigrations in peripheral vasculature during the inflammatory response.