Hyperlipidemia: a risk factor for chronic allograft dysfunction

Abstract

While the early results of renal transplantation have improved in the last years, but the long-term allograft survival have not improved to the same extent. The major cause of these graft losses is chronic allograft dysfunction (CAD). The pathogenesis of CAD is complex and results from a interaction of immune and nonimmune factors. Between these non-immunological related factors there are two cardiovascular risk factors, hypertension and especially hyperlipidemia, that have been implicated in the development and progression of CAD. Lipid profile abnormalities are very prevalent in renal transplant patients. In last years several authors have reported an association between different lipid profile alterations and CAD. We conducted an observational study in our group to determine the relationship between different lipid disturbances and CAD. The hypertriglyceridemia and the Lp(a)>30 mg/dL before and after transplantation were, between the lipid abnormalities, the two independent risk factors for CAD in a multivarite analysis.