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Review
. 2002 Apr:109 Suppl:S45-55.
doi: 10.1016/s0092-8674(02)00675-x.

The mechanism and regulation of chromosomal V(D)J recombination

Craig H Bassing  1 , Wojciech Swat, Frederick W Alt
Affiliations
Free article
Review

The mechanism and regulation of chromosomal V(D)J recombination

Craig H Bassing et al. Cell. 2002 Apr.
Free article

Abstract

V(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination reaction and how it is regulated during lymphocyte development. We also discuss how defects in the mechanism or regulation of V(D)J recombination can lead to human disease.

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