Sex and the single (double-strand) break
- PMID: 11983162
- DOI: 10.1016/s1097-2765(02)00512-9
Sex and the single (double-strand) break
Abstract
It has been known for some time that DNA double-strand breaks (DSBs) initiate homologous recombination during meiosis. Two recent studies show that the fate of a single DSB in yeast is strongly influenced by the presence of other breaks in the genome, hinting that cell-wide or chromosome-regional mechanisms control the outcome of DSB repair.
Comment on
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Wild-type levels of Spo11-induced DSBs are required for normal single-strand resection during meiosis.Mol Cell. 2002 Apr;9(4):835-46. doi: 10.1016/s1097-2765(02)00498-7. Mol Cell. 2002. PMID: 11983174
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