Review
doi: 10.1016/s0264-410x(02)00089-0.
The advantage of early recognition of HIV-infected cells by cytotoxic T-lymphocytes
Affiliations
- PMID: 11983265
- DOI: 10.1016/s0264-410x(02)00089-0
Item in Clipboard
Review
The advantage of early recognition of HIV-infected cells by cytotoxic T-lymphocytes
Vaccine.
.
Abstract
Accumulating evidence indicates that cytotoxic T-lymphocytes (CTL) play an important role in the clearing of primary and control of chronic human immunodeficiency virus (HIV) infection. Here, we discuss recent findings that indicate that the timing of target cell recognition critically contributes to CTL effectiveness. In this light several problems that have troubled CTL research are discussed. The use of early proteins like Tat and Rev is proposed for future vaccines design.
Similar articles
-
Gene combination raises broad human immunodeficiency virus-specific cytotoxicity.Hum Gene Ther. 2001 Sep 1;12(13):1623-37. doi: 10.1089/10430340152528129. Hum Gene Ther. 2001. PMID: 11535166 Clinical Trial.
-
The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals.Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1781-6. doi: 10.1073/pnas.98.4.1781. Proc Natl Acad Sci U S A. 2001. PMID: 11172028 Free PMC article.
-
Evaluation in rhesus macaques of Tat and rev-targeted immunization as a preventive vaccine against mucosal challenge with SHIV-BX08.DNA Cell Biol. 2002 Sep;21(9):653-8. doi: 10.1089/104454902760330183. DNA Cell Biol. 2002. PMID: 12396607
-
CTL ontogeny and viral escape: implications for HIV-1 vaccine design.Trends Immunol. 2004 Mar;25(3):138-42. doi: 10.1016/j.it.2004.01.004. Trends Immunol. 2004. PMID: 15036041 Review. No abstract available.
-
HIV T cell vaccines, the importance of clades.Vaccine. 2002 May 6;20(15):1918-21. doi: 10.1016/s0264-410x(02)00067-1. Vaccine. 2002. PMID: 11983245 Review.
Cited by
-
HIV-1 neuroimmunity in the era of antiretroviral therapy.Neurobiol Dis. 2010 Mar;37(3):542-8. doi: 10.1016/j.nbd.2009.12.015. Epub 2010 Jan 4. Neurobiol Dis. 2010. PMID: 20044002 Free PMC article. Review.
-
Implications of CTL-mediated killing of HIV-infected cells during the non-productive stage of infection.PLoS One. 2011 Feb 7;6(2):e16468. doi: 10.1371/journal.pone.0016468. PLoS One. 2011. PMID: 21326882 Free PMC article.
-
Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239.J Virol. 2006 Jun;80(12):5875-85. doi: 10.1128/JVI.00171-06. J Virol. 2006. PMID: 16731926 Free PMC article.
-
A single amino acid difference within the alpha-2 domain of two naturally occurring equine MHC class I molecules alters the recognition of Gag and Rev epitopes by equine infectious anemia virus-specific CTL.J Immunol. 2006 Nov 15;177(10):7377-90. doi: 10.4049/jimmunol.177.10.7377. J Immunol. 2006. PMID: 17082657 Free PMC article.
-
The Mamu B 17-restricted SIV Nef IW9 to TW9 mutation abrogates correct epitope processing and presentation without loss of replicative fitness.Virology. 2008 May 25;375(1):307-14. doi: 10.1016/j.virol.2008.02.005. Epub 2008 Mar 6. Virology. 2008. PMID: 18328525 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
