Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2002 Apr 30;99(9):5757-9.
doi: 10.1073/pnas.102173199.

Disentangling the MYC web

David Levens  1
Affiliations
Review

Disentangling the MYC web

David Levens. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Pulling different threads of the MYC web activates different combinations of pathways, yielding different outcomes. Other factors such as the E2Fs may shift the relative outcomes. Biochemical cross-talk is undoubtedly required to coordinate pathways. Growth requires activated metabolism more than cell-cycle activation whereas proliferation needs both; proliferation signals delivered in a nonsupportive setting yield apoptosis, etc. DNA damage relieves genes triggering apoptosis from MYC repression (40).
See this image and copyright information in PMC

Comment on

References

    1. Spencer C A, Groudine M. Adv Cancer Res. 1991;56:1–48. - PubMed
    1. Marcu K B, Bossone S A, Patel A J. Annu Rev Biochem. 1992;61:809–860. - PubMed
    1. Eisenmann R N. Genes Dev. 2001;15:2023–2030. - PubMed
    1. Dang C V. Mol Cell Biol. 2000;19:1–11. - PMC - PubMed
    1. Hecht J L, Aster J C. J Clin Oncology. 2000;18:3707–3721. - PubMed

Substances

LinkOut - more resources