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Review
. 2002 May;3(5):317-27.
doi: 10.1038/nrm805.

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

Damien D'Amours  1 , Stephen P Jackson
Affiliations
Review

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

Damien D'Amours et al. Nat Rev Mol Cell Biol. 2002 May.

Abstract

The Mre11 complex is a multisubunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2. Mutations in the genes that encode components of this complex result in DNA- damage sensitivity, genomic instability, telomere shortening and aberrant meiosis. The molecular defect that underlies these phenotypes has long been thought to be related to a DNA repair deficiency. However, recent studies have uncovered functions for the Mre11 complex in checkpoint signalling and DNA replication.

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