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. 2001 Oct;17(10):1203-8.
doi: 10.2116/analsci.17.1203.

Multiwavelength spectrophotometric resolution of the micro-equilibria of cetirizine

K Y Tam  1 , L Quéré
Affiliations
Free article

Multiwavelength spectrophotometric resolution of the micro-equilibria of cetirizine

K Y Tam et al. Anal Sci. 2001 Oct.
Free article

Abstract

The acid-base properties of the antihistamine (H1 receptor antagonist) cetirizine have been studied by using a previously developed multiwavelength spectrophotometric titration method. A new computational procedure called "Two-Step-Divide-and-Conquer" (TSDC), which applied evolving factor analysis (EFA) and target factor analysis (TFA), has been derived to unravel the micro-equilibria of the triprotic zwitterionic compound from the spectral data. We have demonstrated that a single spectrophotometric titration experiment is sufficient to determine the 12 unknown microconstants and the distribution of microspecies, which are in good agreement with literature values, where available.

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