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Review
. 2002 Mar;2(3):221-5.
doi: 10.1038/nrc743.

Oncogenic resistance to growth-limiting conditions

Mikhail V Blagosklonny  1
Affiliations
Review

Oncogenic resistance to growth-limiting conditions

Mikhail V Blagosklonny. Nat Rev Cancer. 2002 Mar.

Abstract

Many carcinogens are mutagens, indicating that mutagenesis is the driving force of carcinogenesis. But what if we turn this prevailing view on its head? I will argue here that carcinogens are cytostatic and/or cytotoxic, and it is not mutation per se, but clonal selection for resistance to these antiproliferative conditions, that leads to cancer. But why aren't all cytotoxins carcinogenic?

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