[Effect of weight reduction on carbohydrate and fatty-acid metabolism in obese, maturity-onset diabetic patients]

Abstract

In 35 adipose maturity-onset-diabetics (27 women, 8 men, average age 48 years) we examined the influence of a 4--5-week slimming cure on the carbohydrate and fat metabolism. A significant decrease showed the index of ideal weight, volume of adipozytes, fasting free fatty acids concentration, triglyceride content of the liver as well as systolic blood pressure. The decrease of the triglycerides, of cholesterol and of the uric acid level in the serum could not be ascertained statistically. The reduction of weight did not cause an essential change of the basal and stimulated insulin concentrations, whereas the glucose tolerance clearly improved. After an observation period of 36.5 months behaviour of weight and form of therapy are analysed.