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Review
. 2002:497:111-21.
doi: 10.1007/978-1-4615-1335-3_13.

Pathophysiology of infantile spasms

Harry T Chugani  1
Affiliations
Review

Pathophysiology of infantile spasms

Harry T Chugani. Adv Exp Med Biol. 2002.

Abstract

Infantile spasms--seen in West's Syndrome--are often associated with cortical abnormalities. The spasms themselves, however, appear to be generated subcortically. Dr. Chugani reviews the clinical data related to the pathophysiology of infantile spasms and proposes a hypothesis which involves both cortical and subcortical mechanisms.

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