Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2002 Apr;3(4):246-55.
doi: 10.1038/nrm780.

Retro-translocation of proteins from the endoplasmic reticulum into the cytosol

Billy Tsai  1 , Yihong Ye, Tom A Rapoport
Affiliations
Review

Retro-translocation of proteins from the endoplasmic reticulum into the cytosol

Billy Tsai et al. Nat Rev Mol Cell Biol. 2002 Apr.

Abstract

Proteins that are misfolded in the endoplasmic reticulum are transported back into the cytosol for destruction by the proteasome. This retro-translocation pathway has been co-opted by certain viruses, and by plant and bacterial toxins. The mechanism of retro-translocation is still mysterious, but several aspects of this process are now being unravelled.

PubMed Disclaimer

Publication types

LinkOut - more resources