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. 2002 May;8(5):519-21.
doi: 10.3201/eid0805.010337.

Outbreak of Neisseria meningitidis, Edmonton, Alberta, Canada

Gregory J Tyrrell  1 , Linda Chui, Marcia Johnson, Nicholas Chang, Robert P Rennie, James A Talbot; Edmonton Meningococcal Study Group
Affiliations

Outbreak of Neisseria meningitidis, Edmonton, Alberta, Canada

Gregory J Tyrrell et al. Emerg Infect Dis. 2002 May.

Abstract

From December 1999 to April 2001, the greater Edmonton region had 61 cases of invasive meningococcal infection, two fatal. The outbreak was due to Neisseria meningitidis serogroup C, electrophoretic type 15, serotype 2a. Analysis of the strains showed that 50 of 56 culture-confirmed cases were due to a single clone and close relatives of this clone. This strain had not been previously identified in the province of Alberta dating back to January 1997.

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Figures

Figure 1
Figure 1
Neisseria meningitidis cases, Edmonton, Alberta, January 1997 to May 2001.* *Cluster 4 refers to clusters derived from restriction fragment length polymorphism patterns, designated in Figure 2.
Figure 2
Figure 2
A, restriction fragment length polymorphism (RFLP) analysis of Neisseria meningitidis serogroup C strains generated by pulsed-field gel electrophoresis (PFGE) by using the Spe I restriction endonuclease. The strain CDC-413 was used as a control for the PFGE. B, dendogram analysis generated from “A.” Percent identity is shown at the top. The RFLP pattern designation is shown on the right. RFLP patterns not underlined were seen from January 1997 to November 1999. Underlined RFLP patterns were seen from December 1999 to April 2001. The dashed line indicates 85% identity. A 1% tolerance was used to generate the dendogram.
See this image and copyright information in PMC

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