Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Nov;27(6):789-96.

Liver alcohol dehydrogenase in Japanese: high population frequency of atypical form and its possible role in alcohol sensitivity

G Stamatoyannopoulos, S H Chen, M Fukui

Liver alcohol dehydrogenase in Japanese: high population frequency of atypical form and its possible role in alcohol sensitivity

G Stamatoyannopoulos et al. Am J Hum Genet. 1975 Nov.

Abstract

Electrophoretic and quantitative studies reveal that 85% of Japanese carry an atypical liver alcohol dehydrogenase (ADH). The frequency of ADH polymorphism is identical with the reported frequency of alcohol sensitivity in the Japanese population. This identity in population frequencies points to a causative relationship between the two phenomena and suggests that alcohol sensitivity might be due to the increased acetaldehyde formation in individuals carrying the atypical ADH gene.

PubMed Disclaimer

References

    1. N Engl J Med. 1975 Feb 20;292(8):422-3 - PubMed
    1. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed
    1. Biochem Biophys Res Commun. 1972 Sep 5;48(5):1140-6 - PubMed
    1. Biochem Biophys Res Commun. 1965 Oct 8;21(1):78-82 - PubMed
    1. Am J Hum Genet. 1973 Mar;25(2):193-9 - PubMed

Publication types

LinkOut - more resources