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Comment
. 2002 May;160(5):1551-4.
doi: 10.1016/S0002-9440(10)61100-5.

Metalloproteases and adipogenesis: a weighty subject

Jennifer Lilla  1 , Dominique Stickens, Zena Werb
Affiliations
Comment

Metalloproteases and adipogenesis: a weighty subject

Jennifer Lilla et al. Am J Pathol. 2002 May.
No abstract available

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Figures

Figure 1.
Figure 1.
Summary of adipocyte differentiation. a: Preadipocytes grow in stromal ECM rich in fibronectin and fibrillar collagens. b: Once confluent, the cells are committed to differentiate. c: Proteases then extensively remodel the ECM; notably fibronectin is degraded. d: The cytoskeleton is also remodeled and transcription factors initiate changes in gene expression. e: The maturing adipocytes produce lipogenic proteins and deposit basement membrane. f: At the end of differentiation, the adipocytes are round and filled with lipid.
Figure 2.
Figure 2.
Schematic comparison of the protein structure of metalloproteases. Pre, amino-terminal signal sequence; Pro, propeptide with a zinc-interacting thiol group; H, hinge region; Dis, disintegrin-like domain; Cys, cysteine-rich domain; TSP, thrombospondin-1-like motif. (Adapted from Egeblad and Werb and Tang .)
See this image and copyright information in PMC

Comment on

  • ADAM 12 protease induces adipogenesis in transgenic mice.
    Kawaguchi N, Xu X, Tajima R, Kronqvist P, Sundberg C, Loechel F, Albrechtsen R, Wewer UM. Kawaguchi N, et al. Am J Pathol. 2002 May;160(5):1895-903. doi: 10.1016/S0002-9440(10)61136-4. Am J Pathol. 2002. PMID: 12000741 Free PMC article.

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