doi: 10.1006/mcpr.2001.0398.
A newly identified single nucleotide polymorphism in the promoter of the matrix metalloproteinase-1 gene
Affiliations
- PMID: 12005449
- DOI: 10.1006/mcpr.2001.0398
Item in Clipboard
A newly identified single nucleotide polymorphism in the promoter of the matrix metalloproteinase-1 gene
Mol Cell Probes.
2002 Feb.
Abstract
Matrix metalloproteinase-1 (MMP-1) is a member of the matrix metalloproteinase enzyme family that degrades components of the extracellular matrix. Recent studies have demonstrated several polymorphic sites in the promoter of the MMP-1 gene. A newly identified single nucleotide polymorphism (SNP) at position -519 in the promoter region of the MMP-1 gene is reported. This polymorphism consists in a guanine to adenine substitution. A linkage between polymorphisms -519A/G and -1607 1G/2G was also studied.
Similar articles
-
The 2G single nucleotide polymorphism (SNP) in the MMP-1 promoter contributes to high levels of MMP-1 transcription in MCF-7/ADR breast cancer cells.Breast Cancer Res Treat. 2003 Nov;82(2):75-82. doi: 10.1023/B:BREA.0000003948.14026.7c. Breast Cancer Res Treat. 2003. PMID: 14692651
-
Fra-1 targets the AP-1 site/2G single nucleotide polymorphism (ETS site) in the MMP-1 promoter.Eur J Biochem. 2003 Oct;270(20):4216-25. doi: 10.1046/j.1432-1033.2003.03821.x. Eur J Biochem. 2003. PMID: 14519134
-
Matrix metalloproteinase-1 promoter polymorphism 1G/2G is correlated with colorectal cancer invasiveness.Clin Cancer Res. 2001 Aug;7(8):2344-6. Clin Cancer Res. 2001. PMID: 11489811
-
The collagenase-1 (MMP-1) gene promoter polymorphism - 1607/2G is associated with favourable prognosis in patients with colorectal cancer.Br J Cancer. 2007 Mar 12;96(5):783-92. doi: 10.1038/sj.bjc.6603630. Epub 2007 Feb 20. Br J Cancer. 2007. PMID: 17311017 Free PMC article.
-
[Single nucleotide polymorphism in the matrix metalloproteinases promoter is associated with susceptibility to endometriosis and adenomyosis].Zhonghua Fu Chan Ke Za Zhi. 2005 Sep;40(9):601-4. Zhonghua Fu Chan Ke Za Zhi. 2005. PMID: 16202315 Chinese.
Cited by
-
Estrogen receptor beta and truncated variants enhance the expression of transfected MMP-1 promoter constructs in response to specific mechanical loading.Biol Sex Differ. 2014 Sep 27;5:14. doi: 10.1186/s13293-014-0014-6. eCollection 2014. Biol Sex Differ. 2014. PMID: 25625008 Free PMC article.
-
Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction.J Appl Genet. 2017 Aug;58(3):331-341. doi: 10.1007/s13353-016-0388-8. Epub 2017 Jan 18. J Appl Genet. 2017. PMID: 28101856
-
MMP-1 polymorphism and its relationship to pathological processes.J Biosci. 2009 Jun;34(2):313-20. doi: 10.1007/s12038-009-0035-1. J Biosci. 2009. PMID: 19550047 Review.
-
MMP-2 (-1306 C/T) Polymorphism Affects Serum Matrix Metalloproteinase (MMP)-2 Levels and Correlates with Chronic Obstructive Pulmonary Disease Severity: A Case-Control Study of MMP-1 and -2 in a Tunisian Population.Mol Diagn Ther. 2016 Dec;20(6):579-590. doi: 10.1007/s40291-016-0225-0. Mol Diagn Ther. 2016. PMID: 27412345
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
