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. 1975 Nov 14;254(1):79-85.
doi: 10.1007/BF00561538.

Degradation of deoxyribonucleic acid by guinea pig epidermal extracts

T Miyagawa, M Anai, H Urabe

Degradation of deoxyribonucleic acid by guinea pig epidermal extracts

T Miyagawa et al. Arch Dermatol Res (1975). .

Abstract

The capability of guinea pig epidermal extracts to hydrolyze deoxyribonucleic acid has been studied. The results of investigation by gel filtration on Sephadex G-75 column and by viscometry on the mode of hydrolysis of deoxyribonucleic acid by epidermal extracts revealed that deoxyribonucleic acid was degraded by both endonuclease and exonuclease activities. The exhaustive digestion by epidermal extracts yielded the complete degradation of deoxyribonucleic acid to mononucleosides or further metabolites. The enzyme systems involved in the deoxyribonucleic acid degradation include at least an endonuclease, an exonuclease and a phosphatase.

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References

    1. J Invest Dermatol. 1961 Dec;37:489-95 - PubMed
    1. J Invest Dermatol. 1971 Nov;57(5):330-6 - PubMed
    1. J Invest Dermatol. 1967 Nov;49(5):537-43 - PubMed
    1. J Invest Dermatol. 1967 Feb;48(2):169-73 - PubMed
    1. J Invest Dermatol. 1964 Jun;42:471-8 - PubMed