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. 1975 Dec;13(11-12):849-56.
doi: 10.1007/BF00484415.

6-Phosphogluconate dehydrogenase (PGD) genetics in the mouse: linkage with metabolically related enzyme loci

V M Chapman

6-Phosphogluconate dehydrogenase (PGD) genetics in the mouse: linkage with metabolically related enzyme loci

V M Chapman. Biochem Genet. 1975 Dec.

Abstract

An electrophoretic polymorphism of 6-phosphogluconate dehydrogenase (PGD) has been observed in the subspecies Mus musculus musculus from northern Denmark. M. m. musculus is interfertile with inbred strains of mice, and F1 hybrids with C57BL/6J show a three-banded phenotype. This pattern is consistent with a dimeric enzyme structure with codominant expression of alleles. In backcrosses and the F2 generation, PGD segregated as a singly autosomal gene, designated Pgd, closely linked to Gpd-1 on chromosome 4(1.7 +/- 1.1%). Both gene products are dimers, both require NADP, and these enzymes catalyze sequential steps in metabolism.

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