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. 2002 May 22;124(20):5638-9.
doi: 10.1021/ja026007t.

Enantioselective direct-addition of terminal alkynes to imines catalyzed by copper(I)pybox complex in water and in toluene

Chunmei Wei  1 , Chao-Jun Li
Affiliations

Enantioselective direct-addition of terminal alkynes to imines catalyzed by copper(I)pybox complex in water and in toluene

Chunmei Wei et al. J Am Chem Soc. .

Abstract

Highly enantioselective direct alkyne-imine additions catalyzed by Cu(I)OTf and Evan's pybox ligands were developed in water and in toluene. The process is simple and provides a diverse range of propargylic amine in high ee and good yield.

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