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. 1975 Jul;150(1):129-32.
doi: 10.1042/bj1500129.

Specific binding sites for 5-hydroxytryptamine on rat blood platelets

A H Drummond, J L Gordon

Specific binding sites for 5-hydroxytryptamine on rat blood platelets

A H Drummond et al. Biochem J. 1975 Jul.

Abstract

5-Hydroxytryptamine changes the shape of rat blood platelets by combination with a cinanserin-sensitive receptor which is not associated with the active uptake of 5-hydroxytryptamine. Binding of 5-hydroxy[3H]tryptamine to platelets at 4 degrees C demonstrates the presence of three saturable sites, and the highest-affinity site is apparently this 5-hydroxytryptamine receptor.

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