Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Jun;50(6):877-80.
doi: 10.1136/gut.50.6.877.

Focal nodular hyperplasia of the liver in men: is presentation the same in men and women?

A Luciani  1 , H Kobeiter, P Maison, D Cherqui, E-S Zafrani, D Dhumeaux, D Mathieu
Affiliations

Focal nodular hyperplasia of the liver in men: is presentation the same in men and women?

A Luciani et al. Gut. 2002 Jun.

Abstract

Background: Focal nodular hyperplasia (FNH) of the liver is a benign hepatic lesion relatively common in women. No studies specifically designed to describe the presentation and imaging findings in males have been published.

Aims: The aims of this study were: (a) to describe the clinical and imaging findings in 18 men with FNH, and (b) to compare these data with those observed in 216 women with FNH observed during the same nine year period.

Patients and methods: According to a final diagnosis of FNH assessed either by pathological examination or by magnetic resonance (MR), the medical charts of 18 men with FNH observed at our institution were reviewed. In order to compare clinical and MR presentations, the files of 216 women with a total of 291 FNH lesions, investigated during the same nine year period, were reviewed.

Results: Eighteen FNH lesions, with a mean diameter of 37.5 mm, were demonstrated in the 18 male patients. A total of 291 lesions with a mean diameter of 63.4 mm were comparatively demonstrated in 216 female patients. Mean age at diagnosis was significantly higher in men (p<0.01) and mean FNH size was significantly smaller in men (p<0.001). Surgery was more frequently performed in men (72.2%) than in women (16.7%) (p<0.001).

Conclusions: Our data indicate that FNH is rare in men and that the lesions are smaller and more often atypical than those in women.

PubMed Disclaimer

Comment in

References

    1. Wanless IR, Mawdsley C, Adams R. On the pathogenesis of focal nodular hyperplasia of the liver. Hepatology 1985;5:1194–200. - PubMed
    1. Carlson SK, Johnson CD, Bender CE, et al. CT of focal nodular hyperplasia of the liver. AJR Am J Roentgenol 2000;174:705–12. - PubMed
    1. Choi CS, Freeny PC. Triphasic helical CT of hepatic focal nodular hyperplasia: incidence of atypical findings. AJR Am J Roentgenol 1998;170:391–5. - PubMed
    1. Mathieu D, Rahmouni A, Anglade MC, et al . Focal nodular hyperplasia: assessment with contrast-enhanced turboFlash MR imaging. Radiology 1991;180:25–30. - PubMed
    1. Shamsi K, De Schepper A, Degryse H, et al. Focal nodular hyperplasia of the liver: radiologic findings. Abdom Imaging 1993;18:32–8. - PubMed