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. 2002 Jun;70(6):3277-80.
doi: 10.1128/IAI.70.6.3277-3280.2002.

Segmented filamentous bacteria interact with intraepithelial mononuclear cells

David K Meyerholz  1 , Thomas J Stabel, Norman F Cheville
Affiliations

Segmented filamentous bacteria interact with intraepithelial mononuclear cells

David K Meyerholz et al. Infect Immun. 2002 Jun.

Abstract

Segmented filamentous bacteria (SFB) are found in multiple species and play an important role in the development of mucosal immunity. The mechanism by which the bacteria interact with the immune system has not been well defined. We provide morphologic evidence of direct interaction between SFB and intraepithelial mononuclear cells.

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Figures

FIG. 1.
FIG. 1.
Scanning electron micrographs of ileal tissue with associated SFB. (a) Villi with SFB. Bar = 10 μm. (b) SFB (arrows) attached near M cells (M) of the follicle-associated epithelium. Bar = 10 μm.
FIG. 2.
FIG. 2.
Transmission electron micrographs of SFB attached to the intestinal epithelium. (a) SFB (arrow) attached to the apical portion of the enterocyte. Magnification, ×4,300. (b) SFB extending through an M cell and into intimate association with a mononuclear cell (MC). Magnification, ×4,300. (c) The SFB segments (arrow) which are below the M cell (M) and which are most intimately associated with the mononuclear cell are irregularly shaped and less electron dense. Magnification, ×11,500.
FIG. 2.
FIG. 2.
Transmission electron micrographs of SFB attached to the intestinal epithelium. (a) SFB (arrow) attached to the apical portion of the enterocyte. Magnification, ×4,300. (b) SFB extending through an M cell and into intimate association with a mononuclear cell (MC). Magnification, ×4,300. (c) The SFB segments (arrow) which are below the M cell (M) and which are most intimately associated with the mononuclear cell are irregularly shaped and less electron dense. Magnification, ×11,500.
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