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Clinical Trial
. 2002 May 14;58(9):1404-7.
doi: 10.1212/wnl.58.9.1404.

Safety, tolerability, and efficacy of orally administered cannabinoids in MS

J Killestein  1 , E L J Hoogervorst, M Reif, N F Kalkers, A C Van Loenen, P G M Staats, R W Gorter, B M J Uitdehaag, C H Polman
Affiliations
Clinical Trial

Safety, tolerability, and efficacy of orally administered cannabinoids in MS

J Killestein et al. Neurology. .

Abstract

The authors conducted a randomized, double-blind, placebo-controlled, twofold crossover study in 16 patients with MS who presented with severe spasticity to investigate safety, tolerability, and efficacy of oral Delta(9)-Tetrahydrocannabinol (THC) and Cannabis sativa plant extract. Both drugs were safe, but adverse events were more common with plant-extract treatment. Compared with placebo, neither THC nor plant-extract treatment reduced spasticity. Both THC and plant-extract treatment worsened the participant's global impression.

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