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. 2002 May;58(2):115-8.
doi: 10.1007/s00228-002-0460-7. Epub 2002 Apr 17.

N-acetyltransferase 2 single-nucleotide polymorphisms and risk of gastric carcinoma

José M Ladero  1 , José A G Agúndez, Manuela Olivera, Luis Lozano, Alvaro Rodríguez-Lescure, Manuel Diaz-Rubio, Julio Benítez
Affiliations

N-acetyltransferase 2 single-nucleotide polymorphisms and risk of gastric carcinoma

José M Ladero et al. Eur J Clin Pharmacol. 2002 May.

Abstract

Objective: To explore whether an association exists between the NAT2 genotype and the risk of developing gastric cancer.METHODS. Ninety-nine patients with gastric adenocarcinoma and 258 healthy subjects were analysed for single-nucleotide polymorphisms at the NAT2 gene locus, which give rise to gene variants known to be associated with slow-acetylation status.

Results: The functional NAT2*4 (wild-type) allele is over-represented among patients (40.4% of all allelic variants) compared with control subjects [25.8%, odds ratio (OR) 1.95, 95% confidence interval (CI) 1.36, 2.8]. According to the NAT2 genotype, 69 patients (69.9%) and 119 healthy subjects (46%) were classified as rapid acetylators (OR 2.69, 95% CI 1.6, 4.54).

Conclusions: Our results, which need independent confirmation, suggest that individuals with NAT2 genotypes leading to high levels of NAT2 enzyme activity are at increased risk of developing gastric carcinoma.

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