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. 1975 Dec:127:591-5.
doi: 10.1192/bjp.127.6.591.

Effect of ADP on PGE1 formation in blood platelets from patients with depression, mania and schizophrenia

Y H Abdulla, K Hamadah

Effect of ADP on PGE1 formation in blood platelets from patients with depression, mania and schizophrenia

Y H Abdulla et al. Br J Psychiatry. 1975 Dec.

Abstract

Adenosine diphosphate (ADP) stimulates the synthesis of prostaglandin E1 (PGE1) in lysed platelets from normal subjects, patients with affective illness but not in platelets from cases of schizophrenia. The stimulation is concentration-dependent and follows a curve which is mildly sigmoid in the normal, markedly sigmoid in depression and hyperbolic in mania.

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