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. 1975 Nov;22(6):680-6.
doi: 10.1007/BF03013316.

The myocardial effects of pancuronium

P C Duke, H Fung, J Gartner

The myocardial effects of pancuronium

P C Duke et al. Can Anaesth Soc J. 1975 Nov.

Abstract

The effect of pancuronium on myocardial contractility was studied in three different animal preparations. Pancuronium produced no change in isometric contraction of rabbit atrial or cat papillary muscle but displaced the acetylcholine dose-response curve to the right in the papillary muscle preparations, verifying a muscarinic blocking effect of this drug. In atropinized dogs in vivo pancuronium produced no significant change in the cardiovascular parameters studied. These studies show that pancuronium exerts its cardiovascular effects primarily by blocking muscarinic receptors in the heart.

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References

    1. Arch Int Pharmacodyn Ther. 1971 Feb;189(2):410-2 - PubMed
    1. Br J Anaesth. 1971 Apr;43(4):335-8 - PubMed
    1. Eur J Pharmacol. 1968 Aug;4(1):83-90 - PubMed
    1. Anaesthesia. 1970 Jul;25(3):356-63 - PubMed
    1. Can Anaesth Soc J. 1974 Mar;21(2):147-52 - PubMed

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