Review
doi: 10.1016/s0002-9343(02)01021-5.
Homocysteine and cardiovascular disease: current evidence and future prospects
Affiliations
- PMID: 12015248
- DOI: 10.1016/s0002-9343(02)01021-5
Item in Clipboard
Review
Homocysteine and cardiovascular disease: current evidence and future prospects
Am J Med.
2002 May.
Abstract
Hyperhomocysteinemia is an independent risk factor for cardiovascular disease. Despite the well-known effectiveness of vitamin supplementation in reducing homocysteine levels, it is not known whether lowering of homocysteine levels is associated with a reduction in cardiovascular morbidity and mortality. The aim of this review is to discuss the epidemiologic evidence about the relation between homocysteine and cardiovascular disease, the pathophysiologic mechanisms responsible for the deleterious vascular and hemostatic effects of homocysteine, and studies of the potential benefits of homocysteine-lowering therapy.
Comment in
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Is it time to standardize and to measure blood homocysteine levels in patients with heart disease?Am J Med. 2002 May;112(7):582-3. doi: 10.1016/s0002-9343(02)01107-5. Am J Med. 2002. PMID: 12015254 No abstract available.
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