Review
doi: 10.1016/s1570-0232(02)00114-9.
Database of bronchoalveolar lavage fluid proteins
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- PMID: 12016001
- DOI: 10.1016/s1570-0232(02)00114-9
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Review
Database of bronchoalveolar lavage fluid proteins
J Chromatogr B Analyt Technol Biomed Life Sci.
.
Abstract
Bronchoalveolar lavage during fiberoptic bronchoscopy is extensively used for investigating cellular and biochemical alterations of the epithelial lining fluid in various lung disorders. Two-dimensional electrophoresis (2-DE) offers the possibility to simultaneously display and analyze proteins contained in bronchoalveolar lavage fluid (BALF). We present the current status of 2-DE of BALF samples with an updated listing of the proteins already identified and of their level and/or posttranslational alterations in lung disorders. Alternatives to 2-DE of BALF samples and future prospects of proteomics to unravel lung functions and pathologies are discussed.
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