TranScout: prediction of gene expression regulatory proteins from their sequences
- PMID: 12016057
- DOI: 10.1093/bioinformatics/18.4.597
TranScout: prediction of gene expression regulatory proteins from their sequences
Abstract
Motivation: The advent of genomics yields thousands of reading frames in search of function. Identification of conserved functional motifs in protein sequences can be helpful for function prediction.
Results: A database and a classification of reported DNA-binding protein motifs has been designed. A program ('TranScout') has been developed for the detection and evaluation of conserved motifs in prokaryotic and eukaryotic sequences of proteins with a gene regulatory function. The efficiency of the program is shown in a benchmark against a database obtained from SWISS-PROT without the protein sequences used to train the program. All motifs were detected with a mean average sensitivity of 0.98 and a mean average specificity of 0.92.
Availability: The program is freely available for use on the internet at http://luz.uab.es/transcout/. The user can find additional information at this site.
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