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Comparative Study
. 2002 Apr;18(4):626-30.
doi: 10.1093/bioinformatics/18.4.626.

The SWIB and the MDM2 domains are homologous and share a common fold

Riccardo Bennett-Lovsey  1 , Sarah E Hart, Hiroki Shirai, Kenji Mizuguchi
Affiliations
Comparative Study

The SWIB and the MDM2 domains are homologous and share a common fold

Riccardo Bennett-Lovsey et al. Bioinformatics. 2002 Apr.

Abstract

Using a novel algorithm for protein sequence/structure analysis, we propose a probable homology between the SWIB domain (the conserved domain of the 60 kda subunit of the SWIB complex involved in chromatin remodelling) and the p53-binding domain of the MDM2 oncoprotein. The homology suggests that the SWIB domain would adopt a structure similar to that of the MDM2 domain and that these two families of proteins may share a similar functional mechanism.

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