[Leflunomide in systemic lupus erythematosus]
- PMID: 12017890
[Leflunomide in systemic lupus erythematosus]
Abstract
Leflunomide is an antirheumatic drug. One of its main features is its ability to inhibit de novo pyrimidine ribonucleotide biosynthesis. It has been reported as an effective drug in the treatment of patients with Rheumatoid Arthritis. Recently pilot studies have demonstrated the benefit of leflunomide in systemic lupus erythematosus patients. Herein we describe the successful treatment of two lupus patients with leflunomide and review the current literature.
Similar articles
-
Leflunomide: friend or foe for systemic lupus erythematosus?Rheumatol Int. 2013 Feb;33(2):273-6. doi: 10.1007/s00296-012-2508-z. Epub 2012 Sep 8. Rheumatol Int. 2013. PMID: 22961090 Review.
-
The beneficial effect of leflunomide on systemic lupus erythematosus: the role of Tregs repopulation?: Comment on: Leflunomide: friend or foe for systemic lupus erythematosus? Rheumatol Int 2013, 33(2):273-6.Rheumatol Int. 2014 Jun;34(6):881. doi: 10.1007/s00296-013-2795-z. Epub 2013 Jun 14. Rheumatol Int. 2014. PMID: 23765200 No abstract available.
-
Leflunomide for the treatment of systemic lupus erythematosus: comment on the article by McMurray.Arthritis Rheum. 2001 Oct;45(5):472. doi: 10.1002/1529-0131(200110)45:5<472::aid-art368>3.0.co;2-o. Arthritis Rheum. 2001. PMID: 11642648 No abstract available.
-
Double-blind, randomized, placebo-controlled pilot study of leflunomide in systemic lupus erythematosus.Lupus. 2004;13(8):601-4. doi: 10.1191/0961203304lu1067sr. Lupus. 2004. PMID: 15462490 Clinical Trial.
-
[Collagen diseases and rheumatic diseases].Nihon Naika Gakkai Zasshi. 2004 Mar 10;93(3):538-44. doi: 10.2169/naika.93.538. Nihon Naika Gakkai Zasshi. 2004. PMID: 15052817 Review. Japanese. No abstract available.
Cited by
-
Protective effects of leflunomide against ischemia-reperfusion injury of the rat liver.Pediatr Surg Int. 2006 May;22(5):428-34. doi: 10.1007/s00383-006-1668-x. Epub 2006 Mar 24. Pediatr Surg Int. 2006. PMID: 16555109
-
Effect of leflunomide on immunological liver injury in mice.World J Gastroenterol. 2003 Feb;9(2):320-3. doi: 10.3748/wjg.v9.i2.320. World J Gastroenterol. 2003. PMID: 12532458 Free PMC article.
-
Leflunomide attenuates hepatocyte injury by inhibiting Kupffer cells.World J Gastroenterol. 2004 Jun 1;10(11):1608-11. doi: 10.3748/wjg.v10.i11.1608. World J Gastroenterol. 2004. PMID: 15162534 Free PMC article.
-
A 771726, the active metabolite of leflunomide, inhibits TNF-alpha and IL-1 from Kupffer cells.Inflammation. 2004 Apr;28(2):97-103. doi: 10.1023/b:ifla.0000033025.73363.d3. Inflammation. 2004. PMID: 15379215
-
Leflunomide: friend or foe for systemic lupus erythematosus?Rheumatol Int. 2013 Feb;33(2):273-6. doi: 10.1007/s00296-012-2508-z. Epub 2012 Sep 8. Rheumatol Int. 2013. PMID: 22961090 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical