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. 2002 May 3;1575(1-3):139-42.
doi: 10.1016/s0167-4781(02)00238-5.

The nuclear export signal (NES) found in the amino-terminal region of carp MEK1 and MKK6 is lacking in carp MKK4

Hisashi Hashimoto  1 , Yoshiyuki Matsuo, Yoshihiro Yokoyama, Haruhiko Toyohara, Morihiko Sakaguchi
Affiliations

The nuclear export signal (NES) found in the amino-terminal region of carp MEK1 and MKK6 is lacking in carp MKK4

Hisashi Hashimoto et al. Biochim Biophys Acta. .

Abstract

Carp MKK4 (cMKK4) cDNA was isolated from an ovary cDNA library. cMKK4 mRNA was ubiquitously distributed in various tissues of adult carp. Sequence analysis revealed that cMKK4 lacks a nuclear export signal sequence, unlike mammalian and frog MEKs (ERK activator) and cMKK6 (carp p38 activator), where it plays an important role in anchoring these MAP kinase activators to the cytoplasm. cMKK4 protein was found to be diffused throughout the cell, whereas cMEK1 and cMKK6 proteins were seen exclusively in the cytoplasm.

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