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Comment
. 2002 May;109(10):1287-9.
doi: 10.1172/JCI15816.

Whence nitrotyrosine?

James K Hurst  1
Affiliations
Comment

Whence nitrotyrosine?

James K Hurst. J Clin Invest. 2002 May.
No abstract available

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Figures

Figure 1
Figure 1
Representative pathways for biological formation of 3-nitrotyrosine. This product has been widely assumed to arise from the interaction of secondary oxidants derived from peroxynitrite (ONOO–) with tyrosine-containing proteins. However, several alternative pathways exist, including one mediated by the enzyme myeloperoxidase (MPO), that may be important in respiring tissues. tyr, tyrosine; tyr•, tyrosyl radical.
See this image and copyright information in PMC

Comment on

  • Myeloperoxidase produces nitrating oxidants in vivo.
    Gaut JP, Byun J, Tran HD, Lauber WM, Carroll JA, Hotchkiss RS, Belaaouaj A, Heinecke JW. Gaut JP, et al. J Clin Invest. 2002 May;109(10):1311-9. doi: 10.1172/JCI15021. J Clin Invest. 2002. PMID: 12021246 Free PMC article.

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