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. 2000;4(1 Suppl 2):67-72.

[Adverse reactions associated with the use of L-asparaginase during therapy of patients with nB non-Hodgkin's lymphoma. Report of the Polish Paediatric LeuKaemia/Lymphoma Study Group]

[Article in Polish]
G Wróbel  1 , G Dobaczewski, B Kazanowska, J Bogusławska-Jaworska, W Balwierz, A Balcerska, H Bubała, A Dluzniewska, P Kołecki, J Kowalczyk, A Kurylak, L Maciejka-Kapuscinska, M Matysiak, R Rokicka-Milewska, D Sońta-Jakimczyk, B Sopyło, M J Stefaniak, K Stefańska, E Stańczak, M Wysocki
Affiliations
  • PMID: 12021464

[Adverse reactions associated with the use of L-asparaginase during therapy of patients with nB non-Hodgkin's lymphoma. Report of the Polish Paediatric LeuKaemia/Lymphoma Study Group]

[Article in Polish]
G Wróbel et al. Med Wieku Rozwoj. 2000.

Abstract

The aim of the study was to determine the side effects of asparaginase administration during treatment protocol for childhood non-Hodgkin's lymphoma (NHL). Drug adverse reactions occurred in 20/66 of patients (30,3%) treated in 9 centres in Poland between 1993 and 1998. The most common side effects were coagulation disturbances in 12/66 of the children (18,2%), which occurred due to reduced production of important coagulation factors. Six patients (9,1%) developed impairment of liver function (9,1%). Drug toxicity caused the modifications of treatment protocol in 12/66 (18,2%) of patients, mainly in the induction phase; 3 children died due to relapse of disease.

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