Glucose-insulin-potassium solution for acute myocardial infarction
- PMID: 12022912
- DOI: 10.1345/aph.1A300
Glucose-insulin-potassium solution for acute myocardial infarction
Abstract
Objective: To review the role of glucose-insulin-potassium (GIK) solution in the management of acute myocardial infarction (AMI).
Data sources: MEDLINE (1966-October 2001) database, using the search terms glucose, insulin, potassium, and myocardial infarction.
Study selection: Relevant English-language human studies and meta-analyses.
Data synthesis: Most studies that have investigated the use of GIK in AMI have been from the prethrombolytic era. Although most data trended toward favoring GIK in improving mortality and morbidity of AMI, the Polish GIK study was terminated prematurely because of an increase in mortality in patients treated with GIK. Dosage, duration of treatment, and route of administration of GIK varied among studies.
Conclusions: Until results from larger-scale studies become available, the routine use of GIK infusion in AMI patients is not recommended.
Similar articles
-
Glucose-insulin-potassium infusion as adjunctive therapy in myocardial infarction: current evidence and potential mechanisms.Ital Heart J. 2004 Oct;5(10):727-31. Ital Heart J. 2004. PMID: 15626267
-
Glucose-insulin-potassium therapy in patients with ST-segment elevation myocardial infarction.JAMA. 2007 Nov 28;298(20):2399-405. doi: 10.1001/jama.298.20.2399. JAMA. 2007. PMID: 18042917 Clinical Trial.
-
High-dose glucose-insulin-potassium treatment reduces myocardial apoptosis in patients with acute myocardial infarction.Eur J Clin Invest. 2005 Mar;35(3):164-70. doi: 10.1111/j.1365-2362.2005.01468.x. Eur J Clin Invest. 2005. PMID: 15733070 Clinical Trial.
-
[New evidence of uselessness of intravenous glucose-insulin-potassium infusion in patients with ST-segment elevation myocardial infarction: results of meta-analysis of CREATE-ECLA and OASIS-6 trials].Kardiologiia. 2008;48(1):76. Kardiologiia. 2008. PMID: 18261001 Review. Russian. No abstract available.
-
Glucose-insulin-potassium therapy in the era of coronary revascularization.Cardiol Rev. 2005 Sep-Oct;13(5):266-70. doi: 10.1097/01.crd.0000175287.38905.14. Cardiol Rev. 2005. PMID: 16106190 Review.
Cited by
-
Effect of preinitiated glucose-insulin-potassium strategy for patients with undergoing planned percutaneous coronary intervention: a systematic review and meta-analysis.BMJ Open. 2023 Dec 7;13(12):e073557. doi: 10.1136/bmjopen-2023-073557. BMJ Open. 2023. PMID: 38149412 Free PMC article.
-
Can lessons learned about preventing cardiac muscle death be applied to prevent skeletal muscle death?Bone Joint Res. 2020 Jul 23;9(6):268-271. doi: 10.1302/2046-3758.96.BJR-2019-0241.R1. eCollection 2020 Jun. Bone Joint Res. 2020. PMID: 32728425 Free PMC article. No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical