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Comparative Study
. 2002 Jan-Feb;65(1):3-6.

[Neuroleptic-like activity of the tripeptide neurotensin analog GZR-123]

[Article in Russian]
L S Guzevatykh  1 , R U Ostrovskaia, T A Gudasheva, N I Zaĭtseva, T A Voronina
Affiliations
  • PMID: 12025780
Comparative Study

[Neuroleptic-like activity of the tripeptide neurotensin analog GZR-123]

[Article in Russian]
L S Guzevatykh et al. Eksp Klin Farmakol. 2002 Jan-Feb.

Abstract

The neurotropic activity of GZR-123, a tripeptoid neurotensin analog was studied. It was found that the drug (0.8 mg/kg, i.p.) is capable of attenuating the apomorphine-induced climbing, stereotypy, and hyperactivity (locomotion) in mice, the apomorphine and L-DOPA induced stereotypy in rats, and the L-DOPA induced impairment of extraporatory escape in rats. The same dose neither induce myorelaxation, violated coordination of movements, and sedation, nor affected the emotional and anxiety levels. At a dose 1250 times the ED50 for apomorphine and L-DOPA dependent tests, GZR-123 did not cause acute toxicity and did not provoke catalepsy.

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