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. 2002 May;65(5):779-82.
doi: 10.1021/np010555n.

Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891

Carmen Méndez  1 , Eva Künzel, Fredilyn Lipata, Felipe Lombó, William Cotham, Michael Walla, Daniel W Bearden, Alfredo F Braña, Jose A Salas, Jürgen Rohr
Affiliations

Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891

Carmen Méndez et al. J Nat Prod. 2002 May.

Abstract

Our investigations on the discovery of novel natural metabolites using type II polyketide synthase gene probes (actI/III) yielded an unusual angucyclinone, oviedomycin (2), when applied to the oleandomycin (1) producer Streptomyces antibioticus ATCC11891. The novel natural product was produced using S. albus R(-)M(-) as a host strain, into which a cosmid containing the oviedomycin gene cluster was transformed. Its structure was elucidated by NMR spectroscopy and mass spectrometry.

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