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Case Reports
. 2002 Jun;117(3):620-2.
doi: 10.1046/j.1365-2141.2002.03499.x.

Stevens-Johnson syndrome after treatment with STI571: a case report

Liang-Tsai Hsiao  1 , Hung-Ming Chung, Jen-Tsun Lin, Tzeon-Jye Chiou, Jin-Hwang Liu, Frank S Fan, Wei-Shu Wang, Chueh-Chuan Yen, Po-Min Chen
Affiliations
Case Reports

Stevens-Johnson syndrome after treatment with STI571: a case report

Liang-Tsai Hsiao et al. Br J Haematol. 2002 Jun.

Abstract

Between seven and 21% of patients treated with the specific tyrosine kinase inhibitor STI571 have been reported to develop mild-to-moderate severity of adverse cutaneous reactions. We report a patient in the blast crisis phase of chronic myeloid leukaemia who developed a life-threatening cutaneous reaction, Stevens-Johnson syndrome, following 1 week of STI571 therapy. This report may serve to remind the clinician about the possible severe cutaneous side-effects of STI571 before instituting more extensive clinical application of this agent in the future.

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