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. 2002 Jun 3;12(11):1517-20.
doi: 10.1016/s0960-894x(02)00188-9.

Nicotinanilides as inhibitors of neutrophil chemotaxis

Neil S Cutshall  1 , Kristin A Kucera, Rocky Ursino, John Latham, Nathan C Ihle
Affiliations

Nicotinanilides as inhibitors of neutrophil chemotaxis

Neil S Cutshall et al. Bioorg Med Chem Lett. .

Abstract

A series of 4-fluoronicotinanilides was synthesized and shown to be novel, potent, and selective inhibitors against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, autoimmune, and allergic disorders.

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