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. 2002 Jun 21;941(1-2):107-12.
doi: 10.1016/s0006-8993(02)02614-8.

Nitric oxide and hydroxyl radicals initiate lipid peroxidation by NMDA receptor activation

Yoshihito Hayashi  1 , Yuto Ueda, Akira Nakajima, Hidekatsu Yokoyama, Yoshio Mitsuyama, Hiroaki Ohya-Nishiguchi, Hitoshi Kamada
Affiliations

Nitric oxide and hydroxyl radicals initiate lipid peroxidation by NMDA receptor activation

Yoshihito Hayashi et al. Brain Res. .

Abstract

In this experiment, we used direct electron paramagnetic resonance (EPR) spectra to measure lipid peroxidation by hydroxyl radical (.OH), nitric oxide (.NO) and lipid radical (.L). NMDA-receptor associated lipid peroxidation is thought to act through .OH in induction of neurotoxicity. The origin of .OH generation was found to arise mainly from peroxynitrite anion produced from O(2)(-) and .NO rather than from Fenton's reaction. This study verified that .OH generation from interactive reactions between .NO and O(2)(-) initiates NMDA-induced lipid peroxidation of PC12 cells.

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