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Review
. 2002 May 13;21(21):3391-402.
doi: 10.1038/sj.onc.1205312.

Myeloid differentiation (MyD) primary response genes in hematopoiesis

Dan A Liebermann  1 , Barbara Hoffman
Affiliations
Review

Myeloid differentiation (MyD) primary response genes in hematopoiesis

Dan A Liebermann et al. Oncogene. .

Abstract

Myeloid Differentiation (MyD) primary response and Growth Arrest DNA-Damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45alpha MyD118/Gadd45beta, GADD45gamma, MyD116/Gadd34) genes, that have been cloned by virtue of there being co-ordinately induced upon the onset of terminal myeloid differentiation. This review delineates the role MyD genes play in blood cell development, where they function as positive regulators of terminal differentiation, lineage specific blood cell development and control of blood cell homeostasis, including growth inhibition and apoptosis.

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