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Comparative Study
. 2002 May 28;58(10):1546-50.
doi: 10.1212/wnl.58.10.1546.

Long-term follow up of subthalamic nucleus stimulation in Parkinson's disease

L M A Romito  1 , M Scerrati, M F Contarino, A R Bentivoglio, P Tonali, A Albanese
Affiliations
Comparative Study

Long-term follow up of subthalamic nucleus stimulation in Parkinson's disease

L M A Romito et al. Neurology. .

Abstract

Twenty-two patients with PD received bilateral implants for high frequency stimulation of the subthalamic nucleus. The patients were treated for more than 1 year (up to 36 months). At the last visit, the Unified Parkinson Disease Rating Scale (UPDRS) motor score without medication improved by 50.2% (p < 0.001) and the UPDRS activities of daily living score improved by 68.4% (p < 0.001). The most common long-lasting adverse events were hypophonia and dysarthria; transient events were increased sexuality and mania. The surgical procedure induced transient intraoperative psychosis in seven patients.

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