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Clinical Trial
. 2002 May 28;58(10):1556-9.
doi: 10.1212/wnl.58.10.1556.

Long-term response to zonisamide in patients with West syndrome

Y Suzuki  1 , K Imai, Y Toribe, H Ueda, K Yanagihara, K Shimono, T Okinaga, J Ono, T Nagai, T Matsuoka, T Tagawa, J Abe, Y Morita, Y Fujikawa, H Arai, T Mano, S Okada
Affiliations
Clinical Trial

Long-term response to zonisamide in patients with West syndrome

Y Suzuki et al. Neurology. .

Abstract

The long-term effectiveness of zonisamide (ZNS) was evaluated in 11 patients with West syndrome (7 symptomatic) who had cessation of spasms with ZNS monotherapy. During the follow-up period (24 to 79 months, mean = 53 months), this response was maintained in 7 patients (3 symptomatic, relapse rate = 36%), including 2 children in whom ZNS was successfully discontinued. No serious adverse reactions were noted. ZNS may be both effective and well tolerated for the treatment of West syndrome.

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