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Clinical Trial
. 2002 Apr;19(4):164-8.
doi: 10.1023/a:1014837811353.

Ascorbic acid supplement during luteal phase in IVF

Georg Griesinger  1 , Katharina Franke, Cordelia Kinast, Alexandra Kutzelnigg, Sandra Riedinger, Sandor Kulin, Steven G Kaali, Wilfried Feichtinger
Affiliations
Clinical Trial

Ascorbic acid supplement during luteal phase in IVF

Georg Griesinger et al. J Assist Reprod Genet. 2002 Apr.

Abstract

Purpose: To evaluate the impact of ascorbic acid of different doses as additional support during luteal phase in infertility treatment by means of a prospective, randomized, placebo-controlled, group comparative, double-blind study.

Methods: Voluntary daily oral intake of either ascorbic acid (1, 5, or 10 g/day) or Placebo for 14 days after follicle aspiration for IVF-ET procedure. Data was obtained on 620 cases of women, age <40 years, undergoing first IVF-embryo transfer cycles in two private outpatient infertility clinics. All women were stimulated by the same protocol. The mean age was 31.73 (+/- 4.4 SD) years.

Results: No differences in clinical pregnancy rate and implantation rate were noted in statistical logistic regression analysis between the four intake groups.

Conclusions: There was no clinical evidence of any beneficial effect, as defined by main outcome measures, of ascorbic acid on IVF-ET. Our data suggest there is no obvious value of high dosed intake of vitamin C during luteal phase in infertility treatment.

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References

    1. Paeschke KD. The role of ascorbic acid in ovulation. Zentralbl Gynakol. 1969;91(35):1129–1132. - PubMed
    1. Millar J. Vitamin C–the primate fertility factor? Med Hypotheses. 1992;38:292–295. - PubMed
    1. Wagner F, Hofmann KD, Preibsch W, Koob G. Ascorbic acid content of the human ovary. Zentralbl Gynakol. 1970;92(33):1060–1061. - PubMed
    1. Hoch-Ligeti C, Bourne GH. Changes in the concentration and histological distribution of ascorbic acid in ovaries, adrenals and liver of rats during oestrus cycle. Br J Pathol. 1984;29:400–407. - PMC - PubMed
    1. Deane HW. Histochemical observation on the ovary and oviduct of the albino rat during the oestrus cycle. Am J Anat. 1952;91:363–393. - PubMed

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