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. 2002 Jun;144(4):549-53.
doi: 10.1007/s00221-002-1106-9. Epub 2002 Apr 30.

Direct demonstration of the effects of repetitive transcranial magnetic stimulation on the excitability of the human motor cortex

V Di Lazzaro  1 , A Oliviero, A Berardelli, P Mazzone, A Insola, F Pilato, E Saturno, M Dileone, P A Tonali, J C Rothwell
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Direct demonstration of the effects of repetitive transcranial magnetic stimulation on the excitability of the human motor cortex

V Di Lazzaro et al. Exp Brain Res. 2002 Jun.

Abstract

The effects of repetitive transcranial magnetic stimulation (rTMS; 20 stimuli at 5 Hz at 120% resting motor threshold intensity using a biphasic stimulus pulse) on the excitability of human motor cortex were investigated in two patients who had an electrode implanted into the cervical epidural space. The corticospinal D wave increased in amplitude with successive stimuli, and reached a maximum after three or five pulses. At this stage, the amplitude of the I waves was unchanged, but after a further 10 stimuli an additional I wave was recruited. Both effects were still evident 2 min after the end of the rTMS. The effects are compatible with a short-term increase in cortical excitability during suprathreshold rTMS.

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