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. 2002 Jun 17;12(12):1617-9.
doi: 10.1016/s0960-894x(02)00224-x.

8-Methoxyquinolines as PDE4 inhibitors

Motasim Billah  1 , George M Buckley, Nicola Cooper, Hazel J Dyke, Robert Egan, Ashit Ganguly, Lewis Gowers, Alan F Haughan, Hannah J Kendall, Christopher Lowe, Michael Minnicozzi, John G Montana, Janet Oxford, Joanna C Peake, C Louise Picken, John J Piwinski, Robert Naylor, Verity Sabin, Neng-Yang Shih, Julie B H Warneck
Affiliations

8-Methoxyquinolines as PDE4 inhibitors

Motasim Billah et al. Bioorg Med Chem Lett. .

Abstract

The synthesis and pharmacological profile of a novel series of 2-substituted 8-methoxyquinolines is described. The 2-trifluoromethyl compound was found to be a potent inhibitor of phosphodiesterase type 4 (PDE4).

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