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. 2002 Jun 17;12(12):1683-6.
doi: 10.1016/s0960-894x(02)00195-6.

Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck

David J Calderwood  1 , David N Johnston, Rainer Munschauer, Paul Rafferty
Affiliations

Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck

David J Calderwood et al. Bioorg Med Chem Lett. .

Abstract

A series of pyrrolo[2,3-d]pyrimidines was synthesized and evaluated as inhibitors of Lck. Lck accommodates a diverse set of substituents at N-7. Altering the substituent at N-7 provided compound 13, an orally available lck inhibitor which inhibited TCR mediated IL-2 production after oral dosing.

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