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Clinical Trial
. 2002;52(4):251-5.
doi: 10.1055/s-0031-1299888.

Clinical efficacy of pitavastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in patients with hyperlipidemia. Dose-finding study using the double-blind, three-group parallel comparison

Yasushi Saito  1 , Nobuhiro Yamada, Tamio Teramoto, Hiroshige Itakura, Yoshiya Hata, Noriaki Nakaya, Hiroshi Mabuchi, Motoo Tushima, Jun Sasaki, Yuichiro Goto, Nobuya Ogawa
Affiliations
Clinical Trial

Clinical efficacy of pitavastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in patients with hyperlipidemia. Dose-finding study using the double-blind, three-group parallel comparison

Yasushi Saito et al. Arzneimittelforschung. 2002.

Abstract

Pitavastatin (CAS 147526-32-7, NK-104), the first totally synthetic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor discovered in Japan, was examined. Pitavastatin significantly decreased the serum levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) at doses of 1 mg/day or more, and significant dose-dependence of the effect of this drug was observed within the dose range from 1 mg/day to 4 mg/day. It also significantly decreased the serum levels of triglycerides (TG) within this dose range. There was no dose-dependence of the incidence of adverse reactions to pitavastatin.

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