doi: 10.1038/nm725.
Epub 2002 Jun 3.
siRNA-directed inhibition of HIV-1 infection
Affiliations
- PMID: 12042777
- DOI: 10.1038/nm725
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siRNA-directed inhibition of HIV-1 infection
Nat Med.
2002 Jul.
Abstract
RNA interference silences gene expression through short interfering 21 23-mer double-strand RNA segments that guide mRNA degradation in a sequence-specific fashion. Here we report that siRNAs inhibit virus production by targeting the mRNAs for either the HIV-1 cellular receptor CD4, the viral structural Gag protein or green fluorescence protein substituted for the Nef regulatory protein. siRNAs effectively inhibit pre- and/or post-integration infection events in the HIV-1 life cycle. Thus, siRNAs may have potential for therapeutic intervention in HIV-1 and other viral infections.
Comment in
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RNA interference meets HIV-1: will silence be golden?Nat Med. 2002 Jul;8(7):659-60. doi: 10.1038/nm0702-659. Nat Med. 2002. PMID: 12091895 No abstract available.
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