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. 2002 Jul;8(7):681-6.
doi: 10.1038/nm725. Epub 2002 Jun 3.

siRNA-directed inhibition of HIV-1 infection

Carl D Novina  1 , Michael F Murray, Derek M Dykxhoorn, Paul J Beresford, Jonathan Riess, Sang-Kyung Lee, Ronald G Collman, Judy Lieberman, Premlata Shankar, Phillip A Sharp
Affiliations

siRNA-directed inhibition of HIV-1 infection

Carl D Novina et al. Nat Med. 2002 Jul.

Abstract

RNA interference silences gene expression through short interfering 21 23-mer double-strand RNA segments that guide mRNA degradation in a sequence-specific fashion. Here we report that siRNAs inhibit virus production by targeting the mRNAs for either the HIV-1 cellular receptor CD4, the viral structural Gag protein or green fluorescence protein substituted for the Nef regulatory protein. siRNAs effectively inhibit pre- and/or post-integration infection events in the HIV-1 life cycle. Thus, siRNAs may have potential for therapeutic intervention in HIV-1 and other viral infections.

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